Primary Biliary Cholangitis Insights

Elafibrinor approved by MHRA for treatment of adult patients in the UK

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Recent FDA actions concerning obeticholic acid, a medication for primary biliary cholangitis (PBC), have prompted healthcare professionals to reassess its long-term safety. As a result, there's a growing need to support patients transitioning to other treatments. This situation is complicated by the challenges of securing insurance coverage for newer PBC therapies. Pharmacy times (2025) highlights the importance of developing strategies to navigate these access issues effectively.

Healthcare teams are now tasked with finding ways to ensure patients can access and afford these new treatment options. The article underscores the necessity for a collaborative approach among healthcare providers, patients, and insurance companies to manage PBC effectively in light of the evolving therapeutic landscape.

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PBC FoundationPBC FoundationJan 30, 2025

In addition to the announcement earlier in the week, towards the end of last year the Medicines & Healthcare Products Regulatory Agency (MHRA) in the UK announced the approval of Elafibranor (Iqirvo) to be used in the treatment of adult patients in the UK with Primary Biliary Cholangitis. The National Institute for Health and Care Excellence (NICE) has also recommended Elafibranor for the treatment of PBC.

Elafibranor helps to improve how the liver works by reducing the amount of bile acids the liver produces and reducing the build-up of bile. It also acts by reducing inflammation of the liver. Elafibranor may be given by itself or together with ursodeoxycholic acid (UDCA).

More information can be found on our website: https://www.pbcfoundation.org.uk/new-treatments-for-pbc/

Do revisit the above page for any updates about new treatments.

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PBC FoundationPBC FoundationJan 30, 2025

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